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pede4dThe N-terminus conserved domain UCR1 and UCR2 mentioned above play an important role in dimerization of PDE4D and in the regulation of the catalytic domain [13],Phosphodiesterase 4D (PDE4D) expression is upregulated in angiotensin (Ang) II-induced hypertensive mice. We first established a hypertensive model in wild-type (WT,